TY - JOUR A1 - Pagni, Marco A1 - Ioannidis, Vassilios A1 - Cerutti, Lorenzo A1 - Zahn-Zabal, Monique A1 - Jongeneel, C. Victor A1 - Falquet, Laurent T1 - MyHits: a new interactive resource for protein annotation and domain identification Y1 - 2004/7/1 JF - Nucleic Acids Research JO - Nucl. Acids Res. SP - W332 EP - 335 VL - 32 IS - suppl_2 UR - http://nar.oxfordjournals.org/cgi/content/abstract/32/suppl_2/W332 N2 - The MyHits web server (http://myhits.isb-sib.ch) is a new integrated service dedicated to the annotation of protein sequences and to the analysis of their domains and signatures. Guest users can use the system anonymously, with full access to (i) standard bioinformatics programs (e.g. PSI-BLAST, ClustalW, T-Coffee, Jalview); (ii) a large number of protein sequence databases, including standard (Swiss-Prot, TrEMBL) and locally developed databases (splice variants); (iii) databases of protein motifs (Prosite, Interpro); (iv) a precomputed list of matches ( hits') between the sequence and motif databases. All databases are updated on a weekly basis and the hit list is kept up to date incrementally. The MyHits server also includes a new collection of tools to generate graphical representations of pairwise and multiple sequence alignments including their annotated features. Free registration enables users to upload their own sequences and motifs to private databases. These are then made available through the same web interface and the same set of analytical tools. Registered users can manage their own sequences and annotations using only web tools and freeze their data in their private database for publication purposes. N1 - 10.1093/nar/gkh479 ER -