Legends: 1, KRAB. {ECO:0000255|PROSITE- ProRule:PRU00119}; 2, ZN_FING C2H2-type 1; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 3, ZN_FING C2H2-type 2; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 4, ZN_FING C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042}; 5, ZN_FING C2H2-type 4. {ECO:0000255|PROSITE- ProRule:PRU00042}; 6, ZN_FING C2H2-type 5. {ECO:0000255|PROSITE- ProRule:PRU00042}; 7, ZN_FING C2H2-type 6. {ECO:0000255|PROSITE- ProRule:PRU00042}; 8, ZN_FING C2H2-type 7. {ECO:0000255|PROSITE- ProRule:PRU00042}; 9, ZN_FING C2H2-type 8. {ECO:0000255|PROSITE- ProRule:PRU00042}; 10, ZN_FING C2H2-type 9. {ECO:0000255|PROSITE- ProRule:PRU00042}; 11, ZN_FING C2H2-type 10. {ECO:0000255|PROSITE- ProRule:PRU00042}; 12, ZN_FING C2H2-type 11. {ECO:0000255|PROSITE- ProRule:PRU00042}; 13, ZN_FING C2H2-type 12. {ECO:0000255|PROSITE- ProRule:PRU00042}; 14, ZN_FING C2H2-type 13. {ECO:0000255|PROSITE- ProRule:PRU00042}; 15, ZN_FING C2H2-type 14. {ECO:0000255|PROSITE- ProRule:PRU00042}; 16, ZN_FING C2H2-type 15. {ECO:0000255|PROSITE- ProRule:PRU00042}; 17, ismart:ZnF_C2H2 [T]; 18, ipat:ZINC_FINGER_C2H2_1 [T]; 19, iprf:ZINC_FINGER_C2H2_2 [T]; 20, ismart:KRAB [T]; 21, ipfam:KRAB [T].
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ID ZN549_PONAB Reviewed; 640 AA.
AC Q5RBQ3;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 05-OCT-2016, entry version 69.
DE RecName: Full=Zinc finger protein 549;
GN Name=ZNF549;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 15 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
DR EMBL; CR858585; CAH90807.1; -; mRNA.
DR RefSeq; NP_001125458.1; NM_001131986.1.
DR UniGene; Pab.11567; -.
DR ProteinModelPortal; Q5RBQ3; -.
DR STRING; 9601.ENSPPYP00000011735; -.
DR PRIDE; Q5RBQ3; -.
DR GeneID; 100172366; -.
DR KEGG; pon:100172366; -.
DR CTD; 256051; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q5RBQ3; -.
DR KO; K09228; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 15.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 640 Zinc finger protein 549.
FT /FTId=PRO_0000234584.
FT DOMAIN 27 140 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 217 241 C2H2-type 1; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 247 269 C2H2-type 2; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 275 298 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 304 326 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 332 355 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 361 383 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 389 411 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 417 439 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 445 467 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 473 495 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 501 523 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 529 551 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 557 579 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 585 607 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 613 635 C2H2-type 15. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 613 635 ismart:ZnF_C2H2 [T]
FT MYHIT 503 523 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 334 355 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 529 551 ismart:ZnF_C2H2 [T]
FT MYHIT 445 472 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 363 383 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 419 439 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 361 383 ismart:ZnF_C2H2 [T]
FT MYHIT 391 411 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 332 355 ismart:ZnF_C2H2 [T]
FT MYHIT 475 495 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 417 444 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 361 388 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 473 495 ismart:ZnF_C2H2 [T]
FT MYHIT 529 556 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 585 607 ismart:ZnF_C2H2 [T]
FT MYHIT 615 635 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 217 246 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 27 140 iprf:KRAB [T]
FT MYHIT 222 241 ismart:ZnF_C2H2 [T]
FT MYHIT 304 326 ismart:ZnF_C2H2 [T]
FT MYHIT 304 331 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 447 467 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 445 467 ismart:ZnF_C2H2 [T]
FT MYHIT 27 80 ismart:KRAB [T]
FT MYHIT 275 298 ismart:ZnF_C2H2 [T]
FT MYHIT 529 551 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 501 523 ismart:ZnF_C2H2 [T]
FT MYHIT 389 411 ismart:ZnF_C2H2 [T]
FT MYHIT 557 579 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 332 360 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 557 584 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 417 439 ismart:ZnF_C2H2 [T]
FT MYHIT 587 607 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 306 326 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 277 298 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 585 612 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 473 500 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 557 579 ismart:ZnF_C2H2 [T]
FT MYHIT 501 528 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 613 640 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 247 274 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 389 416 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 182 204 ismart:ZnF_C2H2 [T]
FT MYHIT 27 67 ipfam:KRAB [T]
FT MYHIT 275 303 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 640 AA; 74413 MW; 4E247917465926CE CRC64;
MAAAALVNTP QIPMVTEEFV KPSQGHVTFE DIAVYFSQEE WGLLDEAQRC LYHDVMLENF
LLMASVGCLH GIEAEEAPSE QTISAQGVSQ ARTPKLGPSI PNAHSCEMCI LVMKDILYLT
EHQGTLPWQK PYTSVASGKW FSFGSNLQQH QNQDSGEKHI RKEESSALLL NSCKIPLSDN
LFPCKDVEKD FPTILGLLQH QTTHSREEYA HRSRETFQQR RYKCEQVFNE KVHVTEHQRV
HTGEKAYKRR EYGKSLNSKY SFVEHQRTHN TEKPYVCNVC GKSFLHKQTL VGHQQRIHTR
ERSYVCIECG KSLSSKYSLV EHQRTHNGEK PYVCNVCGKS FRHKQTFVGH QQRIHTGERP
YVCIECGKSF IHSYDRIRHQ RVHTGERAYQ CSECGKSFIY KQSLLDHQRI HTGERPYECK
ECGKAFIHKK RLLEHQRIHT GEKPYACIIC GKSFIRSSDY MRHQRIHTGE RAYECGDCGK
AFISKQTLIK HHKIHTRERP YECSECGKGF YLEVKLLQHQ RIHTREKLCE CNECGKVFSH
QKRLLEHQKV HTGEKPCECS ECGKCFRHRT SLVQHQKVHS GERPYNCTAC EKAFIYKNKL
VEHQRIHTGE KPYECGKCGK AFNKRYSLVR HQKVHITEEP
//
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