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Motif Scan

user: GUEST

Protein Sequence Input Enter a protein sequence in RAW or FASTA or Swiss-Prot format or a db:AC or db:ID identifier examples raw format identifier FASTA format Swiss-Prot format	ID NODAL_MOUSE Reviewed; 354 AA. AC P43021; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 1. DT 19-JAN-2010, entry version 79. DE RecName: Full=Nodal; DE Flags: Precursor; GN Name=Nodal; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE. RC TISSUE=Embryo; RX MEDLINE=93156841; PubMed=8429908; DOI=10.1038/361543a0; RA Zhou X., Sasaki H., Lowe L., Hogan B.L., Kuehn M.R.; RT "Nodal is a novel TGF-beta-like gene expressed in the mouse node RT during gastrulation."; RL Nature 361:543-547(1993). RN [2] RP FUNCTION. RX MEDLINE=96102811; PubMed=8582278; RA Jones C.M., Kuehn M.R., Hogan B.L.M., Smith J.C., Wright C.V.E.; RT "Nodal-related signals induce axial mesoderm and dorsalize mesoderm RT during gastrulation."; RL Development 121:3651-3662(1995). CC -!- FUNCTION: Essential for mesoderm formation and axial patterning CC during embryonic development. CC -!- SUBUNIT: Homodimer; disulfide-linked (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted (By similarity). CC -!- DEVELOPMENTAL STAGE: Expressed in the node during gastrulation. CC Expression is first detected in primitive streak-stage embryos at CC about the time of mesoderm formation. It then becomes highly CC localized in the node at the anterior of the primitive streak. CC -!- SIMILARITY: Belongs to the TGF-beta family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X70514; CAA49914.1; -; mRNA. DR IPI; IPI00116317; -. DR PIR; S29718; S29718. DR UniGene; Mm.57195; -. DR STRING; P43021; -. DR PRIDE; P43021; -. DR Ensembl; ENSMUST00000049339; ENSMUSP00000039653; ENSMUSG00000037171; Mus musculus. DR UCSC; uc007ffy.1; mouse. DR MGI; MGI:97359; Nodal. DR HOGENOM; HBG713475; -. DR HOVERGEN; P43021; -. DR InParanoid; P43021; -. DR NextBio; 293328; -. DR ArrayExpress; P43021; -. DR Bgee; P43021; -. DR CleanEx; MM_NODAL; -. DR Genevestigator; P43021; -. DR GermOnline; ENSMUSG00000037171; Mus musculus. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0009948; P:anterior/posterior axis specification; IMP:MGI. DR GO; GO:0007420; P:brain development; IMP:MGI. DR GO; GO:0045165; P:cell fate commitment; IMP:MGI. DR GO; GO:0042074; P:cell migration involved in gastrulation; IDA:MGI. DR GO; GO:0007368; P:determination of left/right symmetry; IDA:MGI. DR GO; GO:0048546; P:digestive tract morphogenesis; IMP:MGI. DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:MGI. DR GO; GO:0035050; P:embryonic heart tube development; IMP:MGI. DR GO; GO:0009880; P:embryonic pattern specification; IMP:MGI. DR GO; GO:0001892; P:embryonic placenta development; IMP:MGI. DR GO; GO:0060136; P:embryonic process involved in female pregnancy; IMP:MGI. DR GO; GO:0033505; P:floor plate morphogenesis; IMP:MGI. DR GO; GO:0048859; P:formation of anatomical boundary; IMP:MGI. DR GO; GO:0001702; P:gastrulation with mouth forming second; IMP:MGI. DR GO; GO:0040007; P:growth; IEA:InterPro. DR GO; GO:0001947; P:heart looping; IGI:MGI. DR GO; GO:0002085; P:inhibition of neuroepithelial cell differen...; IMP:MGI. DR GO; GO:0060460; P:left lung morphogenesis; IMP:MGI. DR GO; GO:0001889; P:liver development; IMP:MGI. DR GO; GO:0048382; P:mesendoderm development; IMP:MGI. DR GO; GO:0001707; P:mesoderm formation; IMP:MGI. DR GO; GO:0000122; P:negative regulation of transcription from R...; IDA:MGI. DR GO; GO:0001842; P:neural fold formation; IMP:MGI. DR GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription from R...; IGI:MGI. DR GO; GO:0019827; P:stem cell maintenance; IMP:MGI. DR GO; GO:0001831; P:trophectodermal cellular morphogenesis; IMP:MGI. DR GO; GO:0001944; P:vasculature development; IMP:MGI. DR InterPro; IPR001839; TGFb. DR InterPro; IPR017948; TGFb_CS. DR InterPro; IPR001111; TGFb_N. DR InterPro; IPR015615; TGFbeta. DR PANTHER; PTHR11848; TGFbeta; 1. DR Pfam; PF00019; TGF_beta; 1. DR Pfam; PF00688; TGFb_propeptide; 1. DR SMART; SM00204; TGFB; 1. DR PROSITE; PS00250; TGF_BETA_1; 1. DR PROSITE; PS51362; TGF_BETA_2; 1. PE 2: Evidence at transcript level; KW Cleavage on pair of basic residues; Cytokine; Developmental protein; KW Disulfide bond; Glycoprotein; Growth factor; Secreted; Signal. FT SIGNAL 1 26 Potential. FT PROPEP 27 244 Potential. FT /FTId=PRO_0000034000. FT CHAIN 245 354 Nodal. FT /FTId=PRO_0000034001. FT CARBOHYD 73 73 N-linked (GlcNAc...) (Potential). FT DISULFID 254 320 By similarity. FT DISULFID 283 351 By similarity. FT DISULFID 287 353 By similarity. FT DISULFID 319 319 Interchain (By similarity). SQ SEQUENCE 354 AA; 40448 MW; 4CC4021780815356 CRC64; MSAHSLRILL LQACWALLHP RAPTAAALPL WTRGQPSSPS PLAYMLSLYR DPLPRADIIR SLQAQDVDVT GQNWTFTFDF SFLSQEEDLV WADVRLQLPG PMDIPTEGPL TIDIFHQAKG DPERDPADCL ERIWMETFTV IPSQVTFASG STVLEVTKPL SKWLKDPRAL EKQVSSRAEK CWHQPYTPPV PVASTNVLML YSNRPQEQRQ LGGATLLWEA ESSWRAQEGQ LSVERGGWGR RQRRHHLPDR SQLCRRVKFQ VDFNLIGWGS WIIYPKQYNA YRCEGECPNP VGEEFHPTNH AYIQSLLKRY QPHRVPSTCC APVKTKPLSM LYVDNGRVLL EHHKDMIVEE CGCL //
Motif scanning means finding all known motifs that occur in a sequence. This form lets you paste a protein sequence, select the collections of motifs to scan for, and launch the search. A document deals with the interpretation of the match scores. You should consult the home pages of Prosite on ExPASy, Pfam and InterPro for additional information. Warning: The scan might take a few minutes, thus if your proteins of interest are already in the sequence databases (see list), the Query by Protein form is much faster, and the Protein Hub provides a collection of tools that you might find useful.

Parameters
Database of motifs (db description)	perox - PeroxiBase profiles hamap - HAMAP profiles pat - PROSITE patterns freq_pat - PROSITE patterns (frequent match producers) prf - PROSITE profiles pre - More profiles pfam_fs - Pfam HMMs (local models) pfam_ls - Pfam HMMs (global models)

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